![]() ![]() Most of the pregnant women in the area give birth in this hospital. In addition, The People's Hospital of Pingyang County is the only tertiary hospital responsible for the main medical and health services in Pingyang County. The economic development level of Pingyang County is in the middle level of Wenzhou city. The data of this retrospective case–control study were collected from the Information System of The People's Hospital of Pingyang County. This study aimed to investigate the effects of maternal blood parameter levels on neonatal pathological jaundice and to reduce the incidence and consequences of neonatal pathological jaundice by looking for modifiable risk factors. ![]() In this context, it is crucial to first explore the relationship between maternal blood parameter levels and neonatal pathological jaundice. However, little research has been carried out in understanding the relationship between maternal blood factors and neonatal jaundice in China. For example, studies have found that jaundice in yellow babies is more severe and persistent than in white and black babies 24. ![]() Moreover, there is convincing evidence that ethnic, seasonal and sociocultural factors influence the development of neonatal pathological jaundice 20– 23. In addition, white blood cell (WBC) count and the levels of hemoglobin (HGB) have also been found to be associated with an increased risk of neonatal jaundice 13, 18, 19. Current research suggests a possible link between maternal blood factors and neonatal jaundice, such as maternal blood type may be a risk factor for neonatal jaundice 17. Given the correlation between maternal and fetal hemograms 16, abnormal maternal blood parameter levels may be important factors in reflecting the risk of neonatal jaundice early, but these links and mechanisms are poorly understood. Routine blood test as a simple and inexpensive method is being recommended by more and more studies as an initial step to assist in the diagnosis of neonatal pathological jaundice 14, 15. Neonatal pathological jaundice has been found to be influenced by a variety of medical, maternal and neonatal factors, such as gestational age, birth weight, family history of jaundice, maternal diseases and blood factors 9– 13. Even survivors may suffer from various neurological sequelae such as hearing loss and gaze palsy 8. It can cause bilirubin encephalopathy or kernicterus if not diagnosed and treated promptly 7. Pathological jaundice, which accounts for about 25% of neonatal jaundice, is characterized by rapidly rising bilirubin concentrations in newborns 5, 6. Physiological jaundice usually appears 2–3 days of life and resolves spontaneously without treatment 4. Neonatal jaundice can be divided into physiological jaundice and pathological jaundice. It is often clinically manifested as a yellowish discoloration of the eye sclera and skin 3. Neonatal jaundice is one of the most common clinical conditions, occurring in approximately 80% of preterm infants and 60% of term infants during the first week of life 1, 2. Regular obstetric examinations and routine blood tests are essential to initiate adapted care. Among neonates, those whose mothers had high levels of WBC count and MCV were at increased risk of pathological jaundice. Besides, neonates whose mothers had a high mean corpuscular volume (MCV) during pregnancy doubled the odds of developing pathological jaundice (OR = 1.967 95% CI 1.043–3.711 P = 0.037). Logistic regression results showed that the odds ratio for pathological jaundice in neonates of mothers with high white blood cell (WBC) count was 1.512 (95% CI 1.145–1.998 P = 0.004). 258 neonates (19.71%) were diagnosed with pathological jaundice. We performed stepwise logistic regression modeling to identify maternal blood factors associated with neonatal pathological jaundice. All mothers received a complete routine blood test prior to delivery, and outcome was neonatal pathological jaundice. A retrospective case–control study of 1309 newborns and their mothers from 2019 to 2020 in a single-center tertiary hospital. This study aims to investigate the association between maternal blood parameters and the risk of neonatal pathological jaundice. ![]()
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